C-RED 2 camera from First Light Imaging: a great solution for small animals imaging
INNOVIDEA is pleased to share the detailed white paper about the use of the C-RED 2 from my partner First Light Imaging in the most advanced SWIR fluorescence technologies. Go for an outstanding performing tool for helping help your research in pharmaceutical, diagnostic or surgery. Feel free to contact us should you require additional infos.
Leida technologies releases improved version of OQaPI image post processing software
INNOVIDEA’s partner Leida technologies announces that a new version of its OQaPI software for phase images processing in microscopy is available. Thanks to a machine learning system, the process time has been reduced by a factor of 4. This version supports French and English languages (with automatic language detection).
OQaPI is a software, compatible with ImageJ, allowing to get two types of phase images: Differential Phase-Contrast images and phase images. Another functionality of OQaPI is calculating a bright field image: with some objects, this method presents a better spatial resolution than the one given by classical bright field illumination (Köhler illumination).
The brand new C-Blue One camera from First Light imaging (Innovidea’s partner) belongs to this category. This high resolution 1 608 x 1 104, high speed 660 fps, low noise <3e-, global shutter visible CoaxPress camera can be used in both astronomy/adaptive optics for guides stars and also in microscopy for Förster Resonance Energy Transfer. Want to know more ? Contact us.
INNOVIDEA is delighted to help Leida Technologies launching internationally Altamira, its multimodal phase imaging kit for optical transmission microscopes .
Altamira is a turnkey, affordable solution compatible with many microscope brands and models (Leica, Leitz, Nikon, Olympus, Realux, Zeiss,…). It opens advanced microscopy observation possibilities; real time differential phase contrast, anomal phase contrast, 3D reconstruction.
It is an ideal solution for many fields such as microbiology, oceanography, palinology, pharmaceutical or chemical industry. More to discover about blood disease, plankton, pollen,…
INNOVIDEA proposes now in France the Claxon CXP4 CoaXPress2.0 frame grabber from BITFLOW.
Offering twice the speed of CoaXPress 1.1, this frame grabber supports up to 4 cameras in CXP12 ou CXP10 and is therefore ideal for multicamera systems. User can benefit of a single coax with 12Gb/s data rate up to 30 meters. Contact us for more information.
Based on a spatial and chromatic structuring of light, the illumination source μlight Gen II from LeidaTechnologies – partner of INNOVIDEA – innovates in transmission optical microscopy.
It allows observation in conventional techniques (brightfield, darkfield, phase contrast) with very fine adjustment of colorimetry and easy automation via its software μLight CS (SDK available). Usable with conventional microscopes, old or new, inverted or straight, it allows observations generally not accessible on these instruments: oblique illumination, differential phase contrast or with brightfield lenses, on-line digital holography, Fourier ptychography.
The main applications cover life sciences (cell imaging, microbiology), food and materials (particle analysis, polymers, optics).
A glimpse on new biomarker imagingfrom INNOVIDEA & FLI
Living tissue have capability to absorb and scatter photon at different depth, depending on light wavelength. For long, Near Infrared (NIR-I i.e. 700 to 950nm) portion of spectrum have demonstrated good penetration capability and have allowed various fluorescence imaging for in-vivo, thanks to contrast agent or dyes called fluophore. Several imaging techniques in this band were possible thanks to highly sensitive CDD or S-CMOS for the benefit of biomedical research or clinical application.
Recently, the shift to higher wavelength fluorescence imaging in SWIR or NIR II (1000nm to 1350nm) region has drawn great attention worldwide. Here are a few example of research and innovation in this field:
New fluorescent nanomaterials called NIR-I to NIR-II – such as carbon nanotubes, quantum dots or polymer nanoparticles – replace or complement fluophore. They allow imaging in SWIR band, their light emission when excited in the NIR band. This reduces interference of photon absorption, scattering and autofluorescence.
Recent progress in fluorescent DNA aptamers permits to recognize cancer biomarkers on soluble or membrane bound form. Other works conducted this time with RNA aptamer tags have open the possibility to look into intracellular processes for better understanding cellular signaling and physiology.
Another promising technology for instance makes use of SWIR light for exciting various rare earth nanocrystals dyes that accumulate at disease sites. It allows earlier detection of cancer than MRI or NIR imaging.Finally, for medical use, existing probes like the Indocyanine Green (ICG) which is FDA approved and widely used, is now known to have strong emission in the infrared, greatly simplifying the process for new therapeutic applications or experimentations.
The scope of applications is large, especially in
cancer domain but not only, as can be seen in this non exhaustive list:
In-vivo pre and post treatment,
Therapy, or sometimes both diagnosis and therapy at same time,
Surgery (suppressing need for lymph node biopsies),
Mass spectrometry imaging, …
The C-RED 2 cameras from First Light Imaging use at -40°C have shown their outstanding capability thanks to the unique combination of performances (readout noise <30 electrons, 600FPS frame rate and 93dB dynamic range at the same time). They outperform deeper cooled cameras at a more affordable cost.
Drone payload for methane detection, quantifcation and localization
Methane CH4 is a critical greenhouse gas after C02 that has a high power of global warming. It is therefore essential to limit its non natural emission portion especially as scientists worry about permafrost defreezing.
Oil & gas companies have recently recognized the stake linked to fugitive emission that may arise to their assets along all process cycle (drilling, transport, storage, refining). The new biogas industry must also look into it. It is mandatory to fight efficiently any industrial leaks that can be found.
Infrared Cameras Inc turnkey and off the shelf solution for drone (UAV/UAS) in Optical Gas Imaging camera and spectrometer (represented by INNOVIDEA in Europe) constitute an efficient answer already with proven track in North America. The VGA Mirage camera coupled with 20Mpixels Sony and TDLAS spectrometer, all real time controlled from the ground through a single control module allow accurate detection and quantification. Cost of their use is quickly amortized when you add the decrease of accident risks, gas savings and impact on environment.